1WZY
Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
Summary for 1WZY
Entry DOI | 10.2210/pdb1wzy/pdb |
Descriptor | Mitogen-activated protein kinase 1, 1-ALLYL-5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (3 entities in total) |
Functional Keywords | erk2, inhibitor, kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 42598.85 |
Authors | Kinoshita, T. (deposition date: 2005-03-10, release date: 2005-12-20, Last modification date: 2024-03-13) |
Primary citation | Kinoshita, T.,Warizaya, M.,Ohori, M.,Sato, K.,Neya, M.,Fujii, T. Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative Bioorg.Med.Chem.Lett., 16:55-58, 2006 Cited by PubMed: 16242327DOI: 10.1016/j.bmcl.2005.09.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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