1U7T

Crystal Structure of ABAD/HSD10 with a Bound Inhibitor

Summary for 1U7T

Entry DOI	10.2210/pdb1u7t/pdb
Descriptor	3-hydroxyacyl-CoA dehydrogenase type II, 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, rossmann fold, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : Q99714
Total number of polymer chains	4
Total formula weight	111748.30
Authors	Kissinger, C.R.,Rejto, P.A.,Pelletier, L.A.,Showalter, R.E.,Villafranca, J.E. (deposition date: 2004-08-04, release date: 2004-10-05, Last modification date: 2024-04-03)
Primary citation	Kissinger, C.R.,Rejto, P.A.,Pelletier, L.A.,Thomson, J.A.,Showalter, R.E.,Abreo, M.A.,Agree, C.S.,Margosiak, S.,Meng, J.J.,Aust, R.M.,Vanderpool, D.,Li, B.,Tempczyk-Russell, A.,Villafranca, J.E. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics J.Mol.Biol., 342:943-952, 2004 Cited by PubMed: 15342248 DOI: 10.1016/j.jmb.2004.07.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation