1T4E
Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor
Summary for 1T4E
| Entry DOI | 10.2210/pdb1t4e/pdb |
| Related | 1RV1 1T4F 1YCR |
| Descriptor | Ubiquitin-protein ligase E3 Mdm2, (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID (3 entities in total) |
| Functional Keywords | mdm2-inhibitor complex, ligase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus, nucleoplasm: Q00987 |
| Total number of polymer chains | 2 |
| Total formula weight | 23474.48 |
| Authors | Grasberger, B.L.,Schubert, C.,Koblish, H.K.,Carver, T.E.,Franks, C.F.,Zhao, S.Y.,Lu, T.,LaFrance, L.V.,Parks, D.J. (deposition date: 2004-04-29, release date: 2005-02-08, Last modification date: 2023-08-23) |
| Primary citation | Grasberger, B.L.,Lu, T.,Schubert, C.,Parks, D.J.,Carver, T.E.,Koblish, H.K.,Cummings, M.D.,LaFrance, L.V. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48:909-912, 2005 Cited by PubMed: 15715460DOI: 10.1021/jm049137g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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