1T4E
Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ubiquitin-protein ligase E3 Mdm2 | polymer | 96 | 11156.1 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2 |
| 2 | C, D (A, B) | (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID | non-polymer | 581.2 | 2 | Chemie (DIZ) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22312.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1162.4 | |
| All* | Total formula weight | 23474.5 |
