1SGU

Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease

Summary for 1SGU

• Entry DOI: 10.2210/pdb1sgu/pdb
• Related: 1SH9
• Descriptor: POL polyprotein, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total)
• Functional Keywords: active site mutations, non-active site mutations, indinavir, hiv-1 protease, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 2
• Total formula weight: 22285.22

Authors

Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Govindasamy, L.,Reutzel, R.,Mckenna, R.,Abandje-McKenna, M.,Goodenow, M.M.,Dunn, B.M. (deposition date: 2004-02-24, release date: 2004-10-05, Last modification date: 2024-02-14)

• Primary citation: Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Whitford, L.R.,Govindasamy, L.,Reutzel, R.,McKenna, R.,Agbandje-McKenna, M.,Goodenow, M.M.,Dunn, B.M.; Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.; Biochemistry, 43:12141-12151, 2004; PubMed: 15379553; DOI: 10.1021/bi049459m

Experimental method

X-RAY DIFFRACTION (1.9 Å)