1RPI
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Summary for 1RPI
Entry DOI | 10.2210/pdb1rpi/pdb |
Related | 1rq9 1rv7 |
Descriptor | protease, alpha-D-glucopyranose (3 entities in total) |
Functional Keywords | hiv protease, aids, polyprotein, hydrolase, aspartyl portease, multi-drug resistance |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 21659.37 |
Authors | Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. (deposition date: 2003-12-03, release date: 2004-12-07, Last modification date: 2024-02-14) |
Primary citation | Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity. J.Virol., 78:3123-3132, 2004 Cited by PubMed: 14990731DOI: 10.1128/JVI.78.6.3123-3132.2004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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