1RPI
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10739.6 | 2 | GenBank (6179841) Pfam (PF00077) UniProt (by SIFTS) (Q9QM22) | Human immunodeficiency virus 1 | |
| 2 | C (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (GenBank: 6179841)
| PDB | External Database | Details |
|---|---|---|
| Asn 25 | Asp 25 | engineered mutation |
| Val 36 | Met 36 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21479.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 180.2 | |
| All* | Total formula weight | 21659.4 |
