1RV7

Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity

Summary for 1RV7

Entry DOI	10.2210/pdb1rv7/pdb
Related	1rpi 1rq9
Descriptor	protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE (3 entities in total)
Functional Keywords	hiv protease, aids, polyprotein, hydrolase, aspartyl protease, multi-drug resistance, lopinavir
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22108.02
Authors	Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. (deposition date: 2003-12-12, release date: 2004-12-14, Last modification date: 2024-02-14)
Primary citation	Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity. J.Virol., 78:3123-3132, 2004 Cited by PubMed: 14990731 DOI: 10.1128/JVI.78.6.3123-3132.2004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation