1RQ9
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Summary for 1RQ9
Entry DOI | 10.2210/pdb1rq9/pdb |
Related | 1rpi 1rv7 |
Descriptor | protease, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE (3 entities in total) |
Functional Keywords | hiv protease, aids, polyprotein, hydrolase, aspartyl protease, multi-drug resistance |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22015.88 |
Authors | Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. (deposition date: 2003-12-04, release date: 2004-12-07, Last modification date: 2024-04-03) |
Primary citation | Logsdon, B.C.,Vickrey, J.F.,Martin, P.,Proteasa, G.,Koepke, J.I.,Terlecky, S.R.,Wawrzak, Z.,Winters, M.A.,Merigan, T.C.,Kovari, L.C. Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity. J.Virol., 78:3123-3132, 2004 Cited by PubMed: 14990731DOI: 10.1128/JVI.78.6.3123-3132.2004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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