1RDT
Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer
Summary for 1RDT
Entry DOI | 10.2210/pdb1rdt/pdb |
Related | 1FM6 1FM9 |
Descriptor | Retinoic acid receptor RXR-alpha, LxxLL motif coactivator, Peroxisome proliferator activated receptor gamma, ... (7 entities in total) |
Functional Keywords | hormone, receptor, polymorphism, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 P37231 |
Total number of polymer chains | 4 |
Total formula weight | 65772.21 |
Authors | Haffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G. (deposition date: 2003-11-06, release date: 2004-11-09, Last modification date: 2023-08-23) |
Primary citation | Haffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G.,Consler, T.G.,Bledsoe, R.K.,Ayscue, A.,Croom, D. Structure-based design of potent retinoid X receptor alpha agonists. J.Med.Chem., 47:2010-2029, 2004 Cited by PubMed: 15056000DOI: 10.1021/jm030565g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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