1R0A

Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms

Summary for 1R0A

• Entry DOI: 10.2210/pdb1r0a/pdb
• Related: 1HYS 1N5Y 1N6Q
• Descriptor: 5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*GP*GP*T)-3', 5'-D(*C*CP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*AP*GP*CP*GP*CP*CP*GP*(2DA))-3', Reverse transcriptase, ... (10 entities in total)
• Functional Keywords: hiv-1, transferase, immune system, dna, transferase-immune system-dna complex, transferase/immune system/dna
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 6
• Total formula weight: 176881.90

Authors

Tuske, S.,Ding, J.,Arnold, E. (deposition date: 2003-09-19, release date: 2004-08-03, Last modification date: 2021-10-27)

• Primary citation: Peletskaya, E.N.,Kogon, A.A.,Tuske, S.,Arnold, E.,Hughes, S.H.; Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA.; J.Virol., 78:3387-3397, 2004; PubMed: 15016861; DOI: 10.1128/JVI.78.7.3387-3397.2004

Experimental method

X-RAY DIFFRACTION (2.8 Å)