1PZP

TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor

Summary for 1PZP

Entry DOI	10.2210/pdb1pzp/pdb
Related	1PZO
Descriptor	Beta-lactamase TEM, 3-(4-PHENYLAMINO-PHENYLAMINO)-2-(1H-TETRAZOL-5-YL)-ACRYLONITRILE (3 entities in total)
Functional Keywords	beta-lactamase, novel allosteric inhibitor, core-disruption, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	29591.73
Authors	Horn, J.R.,Shoichet, B.K. (deposition date: 2003-07-14, release date: 2004-03-09, Last modification date: 2021-10-27)
Primary citation	Horn, J.R.,Shoichet, B.K. Allosteric inhibition through core disruption. J.Mol.Biol., 336:1283-1291, 2004 Cited by PubMed: 15037085 DOI: 10.1016/j.jmb.2003.12.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation