1PZP
TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-lactamase TEM | polymer | 263 | 28985.1 | 1 | UniProt (P62593) Pfam (PF00144) Pfam (PF13354) In PDB | Escherichia coli | TEM-1; TEM-2; TEM-3; TEM-4; TEM-5; TEM-6; TEM-8/CAZ-2; TEM-16/CAZ-7; TEM-24/CAZ-6; IRT-4; Penicillinase; TEM beta-lactamase; ampicillin resistance protein |
| 2 | A | 3-(4-PHENYLAMINO-PHENYLAMINO)-2-(1H-TETRAZOL-5-YL)-ACRYLONITRILE | non-polymer | 303.3 | 2 | Chemie (FTA) | |||
| 3 | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 26 - 288 (UniProt: P62593)
| PDB | External Database | Details |
|---|---|---|
| Arg 100 | Asn 98 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28985.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 606.6 | |
| All* | Total formula weight | 29591.7 |
