1P9M

Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

Summary for 1P9M

Entry DOI	10.2210/pdb1p9m/pdb
Descriptor	Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain (3 entities in total)
Functional Keywords	ig domain, four helix bundle, cytokine, interleukin-6, gp130, signaling protein-cytokine complex, signaling protein/cytokine
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189 Secreted: P05231 Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P08887
Total number of polymer chains	3
Total formula weight	78253.48
Authors	Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C. (deposition date: 2003-05-12, release date: 2003-07-01, Last modification date: 2023-08-16)
Primary citation	Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C. Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex Science, 300:2101-2104, 2003 Cited by PubMed: 12829785 DOI: 10.1126/science.1083901 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.65 Å)

Structure validation