1P9M

Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005125	molecular_function	cytokine activity
B	0005138	molecular_function	interleukin-6 receptor binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006955	biological_process	immune response
B	0030154	biological_process	cell differentiation
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL

Chain	Residue	Details
B	CYS73-LEU98

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site_id	PS01354
Number of Residues	42
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL

Chain	Residue	Details
C	LEU195-LEU236

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Not glycosylated => ECO:0000269|PubMed:10066782

Chain	Residue	Details
C	ASN226
A	ASN61

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10066782, ECO:0000269|PubMed:28060820

Chain	Residue	Details
C	ASN202
A	ASN135

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28060820

Chain	Residue	Details
C	ASN226

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