1NKM

Complex structure of HCMV Protease and a peptidomimetic inhibitor

Summary for 1NKM

• Entry DOI: 10.2210/pdb1nkm/pdb
• Related: 1NJT 1NJU 1NKK 2WPO
• Related PRD ID: PRD_000283
• Descriptor: Assemblin, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
• Functional Keywords: protease, peptidomimetic inhibitor, induced-fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human herpesvirus 5 (Human cytomegalovirus)
• Cellular location: Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
• Total number of polymer chains: 2
• Total formula weight: 56979.03

Authors

Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L. (deposition date: 2003-01-03, release date: 2003-02-11, Last modification date: 2024-03-13)

• Primary citation: Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L.; Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease; Biochemistry, 42:885-891, 2003; PubMed: 12549906; DOI: 10.1021/bi027045s

Experimental method

X-RAY DIFFRACTION (2.7 Å)