1NJU

Complex structure of HCMV Protease and a peptidomimetic inhibitor

Summary for 1NJU

Entry DOI	10.2210/pdb1nju/pdb
Related	1NJT 1NKK 1NKM
Related PRD ID	PRD_000283
Descriptor	Assemblin, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide (2 entities in total)
Functional Keywords	protease, peptidomimetic inhibitor, induced-fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human herpesvirus 5 (Human cytomegalovirus)
Cellular location	Protease precursor: Host cytoplasm. Assemblin: Host nucleus. Assembly protein: Host nucleus: P16753
Total number of polymer chains	4
Total formula weight	115393.94
Authors	Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L. (deposition date: 2003-01-02, release date: 2003-02-11, Last modification date: 2024-03-13)
Primary citation	Khayat, R.,Batra, R.,Qian, C.,Halmos, T.,Bailey, M.,Tong, L. Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease Biochemistry, 42:885-891, 2003 Cited by PubMed: 12549906 DOI: 10.1021/bi027045s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation