1J5O

CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER

Replaces:  1C9R

Summary for 1J5O

• Entry DOI: 10.2210/pdb1j5o/pdb
• Related: 1QE1 2HMI
• Descriptor: 5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', Reverse transcriptase, ... (6 entities in total)
• Functional Keywords: hiv, reverse transcriptase, met184ile, 3tc, protein-dna complex, drug resistance, m184i, transferase-immune system-dna complex, transferase/immune system/dna
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 6
• Total formula weight: 172310.89

Authors

Sarafianos, S.G.,Das, K.,Arnold, E. (deposition date: 2002-05-24, release date: 2002-06-14, Last modification date: 2023-12-27)

• Primary citation: Sarafianos, S.G.,Das, K.,Clark Jr., A.D.,Ding, J.,Boyer, P.L.,Hughes, S.H.,Arnold, E.; Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.; Proc.Natl.Acad.Sci.USA, 96:10027-10032, 1999; PubMed: 10468556; DOI: 10.1073/pnas.96.18.10027

Experimental method

X-RAY DIFFRACTION (3.5 Å)