1IQD

Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.

Summary for 1IQD

• Entry DOI: 10.2210/pdb1iqd/pdb
• Related: 1D7P
• Descriptor: HUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN FACTOR VIII, ... (4 entities in total)
• Functional Keywords: factor viii, c2 domain, antibody, blood coagulation, inhibitor, bo2c11, immune system-blood clotting complex, immune system/blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00451
• Total number of polymer chains: 3
• Total formula weight: 63403.13

Authors

Spiegel Jr., P.C.,Jacquemin, M.,Saint-Remy, J.M.,Stoddard, B.L.,Pratt, K.P. (deposition date: 2001-07-21, release date: 2001-08-15, Last modification date: 2023-12-27)

• Primary citation: Spiegel Jr., P.C.,Jacquemin, M.,Saint-Remy, J.M.,Stoddard, B.L.,Pratt, K.P.; Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.; Blood, 98:13-19, 2001; PubMed: 11418455; DOI: 10.1182/blood.V98.1.13

Experimental method

X-RAY DIFFRACTION (2 Å)