1I9R

STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY

Summary for 1I9R

• Entry DOI: 10.2210/pdb1i9r/pdb
• Descriptor: CD40 LIGAND, IMMUNOGLOBULIN H, IMMUNOGLOBULIN L, ... (4 entities in total)
• Functional Keywords: beta-sheet sandwich, immunoglobulin, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted: P29965
• Total number of polymer chains: 9
• Total formula weight: 189191.30

Authors

Karpusas, M.,Lucci, J.,Ferrant, J.,Benjamin, C.,Hsu, Y.-M. (deposition date: 2001-03-20, release date: 2002-03-20, Last modification date: 2024-11-06)

Primary citation

Karpusas, M.,Lucci, J.,Ferrant, J.,Benjamin, C.,Taylor, F.R.,Strauch, K.,Garber, E.,Hsu, Y.M.
Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.
Structure, 9:321-329, 2001

PubMed Abstract: CD40 ligand (CD40L or CD154), a member of the tumor necrosis factor (TNF) family, plays a critical role in both humoral and cellular immune responses and has been implicated in biological pathways involving epithelial cells, fibroblasts, and platelets. Such a pathway is T cell-mediated B cell activation, a process that occurs through the interaction of CD40L with CD40 receptor expressed on B cells. It results in various B cell responses, including immunoglobulin isotype switching and B cell differentiation and proliferation. These responses can be inhibited by the monoclonal antibody 5c8, which binds with high affinity to CD40L.

PubMed: 11525169
DOI: 10.1016/S0969-2126(01)00590-1

Experimental method

X-RAY DIFFRACTION (3.1 Å)