1I9R

STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 498

Chain	Residue
H	ASP100
H	ASP104
H	ASP106
L	LYS53
L	GLU59

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 499

Chain	Residue
M	GLU59
K	ASP100
K	ASP104
K	ASP106
M	LYS53

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN X 500

Chain	Residue
X	ASP100
X	ASP104
X	ASP106
Y	LYS53
Y	GLU59

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Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LtVKrQGLYYIyaQVtF

Chain	Residue	Details
A	LEU161-PHE177

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR199-HIS205
L	TYR196-HIS202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	417
Details	Domain: {"description":"THD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01387","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"11676606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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