1HCF

Crystal structure of TrkB-d5 bound to neurotrophin-4/5

Summary for 1HCF

• Entry DOI: 10.2210/pdb1hcf/pdb
• Related: 1B8M 1B98 1WWB
• Descriptor: NEUROTROPHIN-4, BDNF/NT-3 GROWTH FACTORS RECEPTOR, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase/hormone, complex(transferase-growth factor), neurotrophin-4/5, trkb receptor, ngf-beta superfamily, immunoglobulin domain, transferase-hormone complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P34130; Membrane; Single-pass type I membrane protein: Q16620
• Total number of polymer chains: 4
• Total formula weight: 51365.50

Authors

Banfield, M.J.,Naylor, R.L.,Robertson, A.G.S.,Allen, S.J.,Dawbarn, D.,Brady, R.L. (deposition date: 2001-05-03, release date: 2001-12-06, Last modification date: 2023-12-13)

Primary citation

Banfield, M.J.,Naylor, R.L.,Robertson, A.G.S.,Allen, S.J.,Dawbarn, D.,Brady, R.L.
Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5
Structure, 9:1191-, 2001

PubMed Abstract: The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of Trk receptor:neurotrophin interaction. Neurotrophin function has been implicated in a number of neurological disorders, including Alzheimer's disease and Parkinson's disease.

PubMed: 11738045
DOI: 10.1016/S0969-2126(01)00681-5

Experimental method

X-RAY DIFFRACTION (2.7 Å)