1HCF

Crystal structure of TrkB-d5 bound to neurotrophin-4/5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
B	0005102	molecular_function	signaling receptor binding
X	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
X	0005030	molecular_function	neurotrophin receptor activity
X	0005886	cellular_component	plasma membrane
X	0006468	biological_process	protein phosphorylation
X	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
Y	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
Y	0005030	molecular_function	neurotrophin receptor activity
Y	0005886	cellular_component	plasma membrane
Y	0006468	biological_process	protein phosphorylation
Y	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A1128

Chain	Residue
A	ARG11

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B1129

Chain	Residue
B	ARG34
B	ARG36
B	HIS85
B	ARG111
B	HOH2007
B	HOH2015

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B1130

Chain	Residue
B	HOH2018
B	ALA8
B	ARG11

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B1131

Chain	Residue
A	ARG84
B	ARG34
B	HOH2019

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Functional Information from PROSITE/UniProt

site_id	PS00248
Number of Residues	14
Details	NGF_1 Nerve growth factor family signature. GCRGVDrrhWvSeC

Chain	Residue	Details
A	GLY77-CYS90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
X	ASN325
Y	ASN325

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7574684

Chain	Residue	Details
X	ASN338
Y	ASN338

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