1GWQ

HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE

Summary for 1GWQ

Entry DOI	10.2210/pdb1gwq/pdb
Related	1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1HCP 1HCQ 1QKT 1QKU 3ERD 3ERT
Descriptor	OESTROGEN RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, RALOXIFENE CORE, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, transactivation, agonist, af2 coactivator, receptor, activator, transcripti regulation, dna-binding, nuclear protein, zinc finger, ster binding, phosphorylation, polymorphism, alternative splicin
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	59498.20
Authors	Pike, A.C.W.,Brzozowski, A.M. (deposition date: 2002-03-22, release date: 2002-08-29, Last modification date: 2023-12-13)
Primary citation	Warnmark, A.,Treuter, E.,Gustafsson, J.-A.,Hubbard, R.E.,Brzozowski, A.M.,Pike, A.C.W. Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha. J.Biol.Chem., 277:21862-, 2002 Cited by PubMed: 11937504 DOI: 10.1074/JBC.M200764200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation