1GPK
Structure of Acetylcholinesterase Complex with (+)-Huperzine A at 2.1A Resolution
Summary for 1GPK
Entry DOI | 10.2210/pdb1gpk/pdb |
Related | 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1HBJ 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP |
Descriptor | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | hydrolase, cholinesterase, huperzine a, alzheimer's disease |
Biological source | TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 61845.65 |
Authors | Dvir, H.,Harel, M.,Chetrit, M.,Silman, I.,Sussman, J.L. (deposition date: 2001-11-05, release date: 2002-08-29, Last modification date: 2023-12-13) |
Primary citation | Dvir, H.,Jiang, H.L.,Wong, D.M.,Harel, M.,Chetrit, M.,He, X.C.,Jin, G.Y.,Yu, G.L.,Tang, X.C.,Silman, I.,Bai, D.L.,Sussman, J.L. X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement Biochemistry, 41:10810-, 2002 Cited by PubMed: 12196020DOI: 10.1021/BI020151+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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