2DFP
X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE
Summary for 2DFP
Entry DOI | 10.2210/pdb2dfp/pdb |
Descriptor | PROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | aged organophosphate, dfp, serine hydrolase, neurotransmitter cleavage, catalytic triad, alpha/beta hydrolase, hydrolase |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 61834.51 |
Authors | Kryger, G.,Millard, C.B.,Silman, I.,Sussman, J.L. (deposition date: 1998-12-07, release date: 1999-06-28, Last modification date: 2023-08-23) |
Primary citation | Millard, C.B.,Kryger, G.,Ordentlich, A.,Greenblatt, H.M.,Harel, M.,Raves, M.L.,Segall, Y.,Barak, D.,Shafferman, A.,Silman, I.,Sussman, J.L. Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. Biochemistry, 38:7032-7039, 1999 Cited by PubMed: 10353814DOI: 10.1021/bi982678l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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