1QTI
Acetylcholinesterase (E.C.3.1.1.7)
Summary for 1QTI
Entry DOI | 10.2210/pdb1qti/pdb |
Related | 1ACJ 1ACL 1AMN 1CFJ 1EVE 1OCE 1VOT 2ACE 2ACK |
Descriptor | ACETYLCHOLINESTERASE, (-)-GALANTHAMINE (3 entities in total) |
Functional Keywords | alzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleaveage, catalytic triad, hydrolase |
Biological source | Torpedo californica (Pacific electric ray) |
Cellular location | Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058 |
Total number of polymer chains | 1 |
Total formula weight | 61023.87 |
Authors | Bartolucci, C.,Perola, E.,Pilger, C.,Fels, G.,Lamba, D. (deposition date: 1999-06-28, release date: 1999-12-29, Last modification date: 2021-06-02) |
Primary citation | Bartolucci, C.,Perola, E.,Pilger, C.,Fels, G.,Lamba, D. Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs Proteins, 42:182-191, 2001 Cited by PubMed: 11119642DOI: 10.1002/1097-0134(20010201)42:2<182::AID-PROT50>3.0.CO;2-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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