1ACJ

QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

Summary for 1ACJ

Entry DOI	10.2210/pdb1acj/pdb
Descriptor	ACETYLCHOLINESTERASE, TACRINE (3 entities in total)
Functional Keywords	hydrolase(carboxylic esterase)
Biological source	Torpedo californica (Pacific electric ray)
Cellular location	Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains	1
Total formula weight	60990.78
Authors	Sussman, J.L.,Harel, M.,Silman, I. (deposition date: 1993-08-18, release date: 1994-08-31, Last modification date: 2024-01-17)
Primary citation	Harel, M.,Schalk, I.,Ehret-Sabatier, L.,Bouet, F.,Goeldner, M.,Hirth, C.,Axelsen, P.H.,Silman, I.,Sussman, J.L. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc.Natl.Acad.Sci.USA, 90:9031-9035, 1993 Cited by PubMed: 8415649 DOI: 10.1073/pnas.90.19.9031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation