1EZF
CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE
Summary for 1EZF
Entry DOI | 10.2210/pdb1ezf/pdb |
Descriptor | FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE, N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID (3 entities in total) |
Functional Keywords | isoprenoid synthase fold, all alpha-helix, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268 |
Total number of polymer chains | 3 |
Total formula weight | 119366.50 |
Authors | Pandit, J.,Danley, D.E.,Schulte, G.K.,Mazzalupo, S.M.,Pauly, T.A.,Hayward, C.M.,Hamanaka, E.S.,Thompson, J.F.,Harwood, H.J. (deposition date: 2000-05-10, release date: 2000-10-18, Last modification date: 2024-02-07) |
Primary citation | Pandit, J.,Danley, D.E.,Schulte, G.K.,Mazzalupo, S.,Pauly, T.A.,Hayward, C.M.,Hamanaka, E.S.,Thompson, J.F.,Harwood Jr., H.J. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. J.Biol.Chem., 275:30610-30617, 2000 Cited by PubMed: 10896663DOI: 10.1074/jbc.M004132200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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