1E7W
One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
Summary for 1E7W
Entry DOI | 10.2210/pdb1e7w/pdb |
Descriptor | PTERIDINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (5 entities in total) |
Functional Keywords | dihydrofolate reductase, pteridine reductase, shortchain dehydrogenase, methotrexate resistance, oxidoreductase |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 2 |
Total formula weight | 64031.62 |
Authors | Gourley, D.G.,Hunter, W.N. (deposition date: 2000-09-11, release date: 2001-09-06, Last modification date: 2024-05-08) |
Primary citation | Gourley, D.G.,Schuttelkopf, A.,Leonard, G.,Luba, J.,Hardy, L.,Beverley, S.,Hunter, W.N. Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites. Nat.Struct.Biol., 8:521-, 2001 Cited by PubMed: 11373620DOI: 10.1038/88584 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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