1E7W
One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | PTERIDINE REDUCTASE | polymer | 291 | 30722.8 | 2 | UniProt (Q9U1F8) Pfam (PF13561) UniProt (by SIFTS) (Q01782) In PDB | LEISHMANIA MAJOR | |
2 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
3 | A, B | METHOTREXATE | non-polymer | 454.4 | 2 | Chemie (MTX) | |||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
5 | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61445.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2585.9 | |
All* | Total formula weight | 64031.6 |