1E7W

One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PTERIDINE REDUCTASE	polymer	291	30722.8	2	UniProt (Q9U1F8) Pfam (PF13561) UniProt (by SIFTS) (Q01782)	LEISHMANIA MAJOR
2	C, G (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	D, H (A, B)	METHOTREXATE	non-polymer		454.4	2	Chemie (MTX)
4	E, F, I (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	J, K (A, B)	water	water		18.0	476	Chemie (HOH)

Sequence modifications

A, B: -3 - -1 (PDB: 1E7W)
A, B: 1 - 288 (UniProt: Q9U1F8)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61445.7
Non-Polymers*	Number of molecules	7
	Total formula weight	2585.9
All*	Total formula weight	64031.6

*Water molecules are not included.