1CXZ

CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1

Summary for 1CXZ

Entry DOI	10.2210/pdb1cxz/pdb
Related	1A2B
Descriptor	PROTEIN (HIS-TAGGED TRANSFORMING PROTEIN RHOA(0-181)), PROTEIN (PKN), MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	protein-protein complex, antiparallel coiled-coil, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 Cytoplasm : Q16512
Total number of polymer chains	2
Total formula weight	30971.42
Authors	Maesaki, R.,Ihara, K.,Shimizu, T.,Kuroda, S.,Kaibuchi, K.,Hakoshima, T. (deposition date: 1999-08-31, release date: 1999-10-08, Last modification date: 2022-12-21)
Primary citation	Maesaki, R.,Ihara, K.,Shimizu, T.,Kuroda, S.,Kaibuchi, K.,Hakoshima, T. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol.Cell, 4:793-803, 1999 Cited by PubMed: 10619026 DOI: 10.1016/S1097-2765(00)80389-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation