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1CXZ

CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000902biological_processcell morphogenesis
A0001764biological_processneuron migration
A0001822biological_processkidney development
A0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
A0002363biological_processalpha-beta T cell lineage commitment
A0003100biological_processregulation of systemic arterial blood pressure by endothelin
A0003189biological_processaortic valve formation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007049biological_processcell cycle
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0007519biological_processskeletal muscle tissue development
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0010975biological_processregulation of neuron projection development
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0021795biological_processcerebral cortex cell migration
A0021861biological_processforebrain radial glial cell differentiation
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030521biological_processandrogen receptor signaling pathway
A0030667cellular_componentsecretory granule membrane
A0031122biological_processcytoplasmic microtubule organization
A0031982cellular_componentvesicle
A0032154cellular_componentcleavage furrow
A0032467biological_processpositive regulation of cytokinesis
A0032587cellular_componentruffle membrane
A0032956biological_processregulation of actin cytoskeleton organization
A0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
A0033688biological_processregulation of osteoblast proliferation
A0034329biological_processcell junction assembly
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035385biological_processRoundabout signaling pathway
A0036089biological_processcleavage furrow formation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042476biological_processodontogenesis
A0042995cellular_componentcell projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043149biological_processstress fiber assembly
A0043197cellular_componentdendritic spine
A0043296cellular_componentapical junction complex
A0043297biological_processapical junction assembly
A0043366biological_processbeta selection
A0043542biological_processendothelial cell migration
A0043931biological_processossification involved in bone maturation
A0044319biological_processwound healing, spreading of cells
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045666biological_processpositive regulation of neuron differentiation
A0045792biological_processnegative regulation of cell size
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0050919biological_processnegative chemotaxis
A0051301biological_processcell division
A0051496biological_processpositive regulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060193biological_processpositive regulation of lipase activity
A0061430biological_processbone trabecula morphogenesis
A0070062cellular_componentextracellular exosome
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071526biological_processsemaphorin-plexin signaling pathway
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090307biological_processmitotic spindle assembly
A0090324biological_processnegative regulation of oxidative phosphorylation
A0097049biological_processmotor neuron apoptotic process
A0097498biological_processendothelial tube lumen extension
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0101003cellular_componentficolin-1-rich granule membrane
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1902766biological_processskeletal muscle satellite cell migration
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903673biological_processmitotic cleavage furrow formation
A1904695biological_processpositive regulation of vascular associated smooth muscle contraction
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A1990869biological_processcellular response to chemokine
A2000177biological_processregulation of neural precursor cell proliferation
A2000406biological_processpositive regulation of T cell migration
A2000672biological_processnegative regulation of motor neuron apoptotic process
B0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 501
ChainResidue
ATHR19
ATHR37
AGSP500
AHOH2004
AHOH2005

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GSP A 500
ChainResidue
ALYS18
ATHR19
ACYS20
APHE30
ATYR34
APRO36
ATHR37
AGLY62
ALYS118
AASP120
ASER160
AALA161
ALYS162
AMG501
AHOH2001
AHOH2002
AHOH2005
AHOH2007
AHOH2075
AHOH2094
AVAL14
AALA15
ACYS16
AGLY17

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER69
AASN117

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
APHE30
AASP59
ASER160

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR34

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR37

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
AASN41

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
AGLN63

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR34

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR37

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
ALYS135

218853

PDB entries from 2024-04-24

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