1BI7
MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
Summary for 1BI7
Entry DOI | 10.2210/pdb1bi7/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR (2 entities in total) |
Functional Keywords | cyclin dependent kinase, cyclin dependent kinase inhibitory protein, cdk, ink4, cell cycle, multiple tumor suppressor, mts1, complex (kinase-anti-oncogene), complex (kinase-anti-oncogene) complex, complex (kinase/anti-oncogene) |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P42771 |
Total number of polymer chains | 2 |
Total formula weight | 53542.91 |
Authors | Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. (deposition date: 1998-06-22, release date: 1999-01-13, Last modification date: 2024-02-07) |
Primary citation | Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395:237-243, 1998 Cited by PubMed: 9751050DOI: 10.1038/26155 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
Download full validation report