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1BI7

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX

Summary for 1BI7
Entry DOI10.2210/pdb1bi7/pdb
DescriptorCYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR (2 entities in total)
Functional Keywordscyclin dependent kinase, cyclin dependent kinase inhibitory protein, cdk, ink4, cell cycle, multiple tumor suppressor, mts1, complex (kinase-anti-oncogene), complex (kinase-anti-oncogene) complex, complex (kinase/anti-oncogene)
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P42771
Total number of polymer chains2
Total formula weight53542.91
Authors
Russo, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P. (deposition date: 1998-06-22, release date: 1999-01-13, Last modification date: 2024-02-07)
Primary citationRusso, A.A.,Tong, L.,Lee, J.O.,Jeffrey, P.D.,Pavletich, N.P.
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395:237-243, 1998
Cited by
PubMed: 9751050
DOI: 10.1038/26155
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.4 Å)
Structure validation

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