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1BI7

MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0001726cellular_componentruffle
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002244biological_processhematopoietic progenitor cell differentiation
A0003323biological_processtype B pancreatic cell development
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006468biological_processprotein phosphorylation
A0007049biological_processcell cycle
A0007165biological_processsignal transduction
A0007219biological_processNotch signaling pathway
A0008285biological_processnegative regulation of cell population proliferation
A0009615biological_processresponse to virus
A0010033biological_processresponse to organic substance
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0010628biological_processpositive regulation of gene expression
A0014002biological_processastrocyte development
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0021542biological_processdentate gyrus development
A0021670biological_processlateral ventricle development
A0030097biological_processhemopoiesis
A0030154biological_processcell differentiation
A0030332molecular_functioncyclin binding
A0033077biological_processT cell differentiation in thymus
A0042063biological_processgliogenesis
A0042127biological_processregulation of cell population proliferation
A0042995cellular_componentcell projection
A0043697biological_processcell dedifferentiation
A0045596biological_processnegative regulation of cell differentiation
A0045638biological_processnegative regulation of myeloid cell differentiation
A0045646biological_processregulation of erythrocyte differentiation
A0045656biological_processnegative regulation of monocyte differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045786biological_processnegative regulation of cell cycle
A0048146biological_processpositive regulation of fibroblast proliferation
A0048699biological_processgeneration of neurons
A0050680biological_processnegative regulation of epithelial cell proliferation
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060218biological_processhematopoietic stem cell differentiation
A0097132cellular_componentcyclin D2-CDK6 complex
A0098770molecular_functionFBXO family protein binding
A0106310molecular_functionprotein serine kinase activity
A1902036biological_processregulation of hematopoietic stem cell differentiation
A2000145biological_processregulation of cell motility
A2000773biological_processnegative regulation of cellular senescence
B0001953biological_processnegative regulation of cell-matrix adhesion
B0003723molecular_functionRNA binding
B0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007049biological_processcell cycle
B0007265biological_processRas protein signal transduction
B0008285biological_processnegative regulation of cell population proliferation
B0019901molecular_functionprotein kinase binding
B0030308biological_processnegative regulation of cell growth
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0035985cellular_componentsenescence-associated heterochromatin focus
B0042326biological_processnegative regulation of phosphorylation
B0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
B0045892biological_processnegative regulation of DNA-templated transcription
B0051059molecular_functionNF-kappaB binding
B0051726biological_processregulation of cell cycle
B0090398biological_processcellular senescence
B0090399biological_processreplicative senescence
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
B2000111biological_processpositive regulation of macrophage apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGKVFkArdlknggrf.........VALK
ChainResidueDetails
AILE19-LYS43

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpqNILV
ChainResidueDetails
AVAL141-VAL153

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
BMET1

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12529334
ChainResidueDetails
BSER7
BSER8
BSER140
BSER152

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR13

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR24

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR49
ATHR70
ATHR325

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:11828325
ChainResidueDetails
ATHR177

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS264

218853

PDB entries from 2024-04-24

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