1B17

PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES)

Summary for 1B17

Entry DOI	10.2210/pdb1b17/pdb
Related	1B17 1B18 1B19 1B2A 1B2B 1B2C 1B2D 1B2E 1B2F 1B2G
Descriptor	PROTEIN (INSULIN A chain), PROTEIN (INSULIN b chain), SULFATE ION, ... (4 entities in total)
Functional Keywords	hormone, glucose concentration decrease, hormone-growth factor complex, hormone/growth factor
Biological source	Sus scrofa (pig) More
Total number of polymer chains	2
Total formula weight	5883.69
Authors	Diao, J.S.,Caspar, D.L.D. (deposition date: 1998-11-22, release date: 2003-04-08, Last modification date: 2024-10-16)
Primary citation	Diao, J. Crystallographic titration of cubic insulin crystals: pH affects GluB13 switching and sulfate binding. Acta Crystallogr.,Sect.D, 59:670-676, 2003 Cited by PubMed Abstract: Structures of porcine insulin crystals soaked in 1 M sodium sulfate at pH 5.00, 5.53, 5.80, 6.00, 6.16, 6.26, 6.35, 6.50, 6.98 and 9.00 have been determined at between 1.7 and 1.9 A resolution. GluB13 exhibits a single conformation at pH PubMed: 12657786 DOI: 10.1107/S0907444903002208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation