11UE
Structure of PDGFRb Kinase Domain Bound to JNJ-PDGFRBi-1
This is a non-PDB format compatible entry.
Summary for 11UE
| Entry DOI | 10.2210/pdb11ue/pdb |
| Descriptor | Platelet-derived growth factor receptor beta, N-[2-(2,2-dimethylpyrrolidin-1-yl)ethyl]-6-methyl-5-({1-methyl-6-[(1-methyl-1H-pyrazol-4-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)pyridine-3-carboxamide (3 entities in total) |
| Functional Keywords | platelet-derived growth factor beta receptor, kinase domain, inhibitor complex, pdgfr-beta, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 49236.19 |
| Authors | |
| Primary citation | Marsboom, G.,Lu, T.,Hong, Z.,Holt, K.,Edmondson, M.,Huang, C.H.,Del Rosario, A.M.,Ibrahim, S.,Wong, V.,Harbut, M.,Jaensch, S.,Liu, Z.,Shi, Y.,Shaffer, P.,Abeywickrema, P.,Duda, D.,Cho, J.H.,Diaz, E.,Wang, W.,Bell-Temin, H.,Riley, D.,Patel, S.,Park, S.,Hinke, S.A.,Nawrocki, A.R.,Yung, L.M.,Schlicker Spain, A.,John, C.,Krosky, D.,Xu, S.S.,Bauman, D.R. Identification of an Inhaled Pulmonary Selective PDGFR Inhibitor with Sustained Target Engagement. J Aerosol Med Pulm Drug Deliv, :19412711261449635-19412711261449635, 2026 Cited by PubMed Abstract: Inhalation of corticosteroids, bronchodilators, antivirals, and antibiotics is well established to treat a variety of pulmonary diseases; however, no inhaled receptor tyrosine kinase (RTK) inhibitors have so far been approved for clinical use despite the key role of RTKs in several pulmonary diseases. We describe a detailed roadmap to identify, optimize, and derisk an inhaled platelet-derived growth factor receptor (PDGFR) inhibitor with extended activity in the lungs. PubMed: 42100928DOI: 10.1177/19412711261449635 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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