11UE
Structure of PDGFRb Kinase Domain Bound to JNJ-PDGFRBi-1
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGQVVeAtahglshsqatmk.....VAVK |
| Chain | Residue | Details |
| A | LEU606-LYS634 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CVHrDLAARNVLI |
| Chain | Residue | Details |
| A | CYS822-ILE834 |
| site_id | PS00240 |
| Number of Residues | 14 |
| Details | RECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GpHlNVVNLLGACT |
| Chain | Residue | Details |
| A | GLY659-THR672 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"UniProtKB","id":"P05622","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"10821867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1314164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15902258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1709159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2550144","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
