9YXQ
Cryo-EM structure of the Xenopus laevis mitotic centromere-associated kinesin (MCAK) bound to the paclitaxel-stabilized microtubule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, F, H, I... (1, 3, 6, 8, A...) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 6 | UniProt (Q2XVP4) | Sus scrofa (pig) | Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain |
| 2 | B, D, E, G, J... (2, 4, 5, 7, B...) | Tubulin beta chain | polymer | 445 | 49907.8 | 6 | UniProt (P02554) | Sus scrofa (pig) | Beta-tubulin |
| 3 | K, N (M, m) | Kinesin-like protein KIF2C | polymer | 739 | 83721.8 | 2 | UniProt (Q91636) | Xenopus laevis (African clawed frog) | Kinesin central motor 1,xKCM1 |
| 4 | BA, DA, GA, IA, KA... (6, 7, 8, A, B...) | MAGNESIUM ION | non-polymer | 24.3 | 11 | Chemie (MG) | |||
| 5 | AA, FA, HA, MA, P... (6, 8, A, a, 1...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 6 | Chemie (GTP) | |||
| 6 | CA, JA, Q, QA, U... (7, B, 2, b, 4...) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 6 | Chemie (GDP) | |||
| 7 | EA, LA, PA, R, W... (7, B, b, 2, 4...) | TAXOL | non-polymer | 853.9 | 6 | Chemie (TA1) |
Sequence modifications
M, m: 1 - 730 (UniProt: Q91636)
| PDB | External Database | Details |
|---|---|---|
| Ser 731 | - | expression tag |
| Asn 732 | - | expression tag |
| Ser 733 | - | expression tag |
| Leu 734 | - | expression tag |
| Glu 735 | - | expression tag |
| Val 736 | - | expression tag |
| Leu 737 | - | expression tag |
| Phe 738 | - | expression tag |
| Gln 739 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 768116.8 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 11189.1 | |
| All* | Total formula weight | 779305.9 |
