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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9YXQ

Cryo-EM structure of the Xenopus laevis mitotic centromere-associated kinesin (MCAK) bound to the paclitaxel-stabilized microtubule

Functional Information from GO Data
ChainGOidnamespacecontents
10000226biological_processmicrotubule cytoskeleton organization
10000278biological_processmitotic cell cycle
10003924molecular_functionGTPase activity
10005200molecular_functionstructural constituent of cytoskeleton
10005525molecular_functionGTP binding
10005737cellular_componentcytoplasm
10005856cellular_componentcytoskeleton
10005874cellular_componentmicrotubule
10007017biological_processmicrotubule-based process
10015630cellular_componentmicrotubule cytoskeleton
10030182biological_processneuron differentiation
20000226biological_processmicrotubule cytoskeleton organization
20000278biological_processmitotic cell cycle
20001764biological_processneuron migration
20003924molecular_functionGTPase activity
20005200molecular_functionstructural constituent of cytoskeleton
20005515molecular_functionprotein binding
20005525molecular_functionGTP binding
20005737cellular_componentcytoplasm
20005856cellular_componentcytoskeleton
20005874cellular_componentmicrotubule
20007017biological_processmicrotubule-based process
30000226biological_processmicrotubule cytoskeleton organization
30000278biological_processmitotic cell cycle
30003924molecular_functionGTPase activity
30005200molecular_functionstructural constituent of cytoskeleton
30005525molecular_functionGTP binding
30005737cellular_componentcytoplasm
30005856cellular_componentcytoskeleton
30005874cellular_componentmicrotubule
30007017biological_processmicrotubule-based process
30015630cellular_componentmicrotubule cytoskeleton
30030182biological_processneuron differentiation
40000226biological_processmicrotubule cytoskeleton organization
40000278biological_processmitotic cell cycle
40001764biological_processneuron migration
40003924molecular_functionGTPase activity
40005200molecular_functionstructural constituent of cytoskeleton
40005515molecular_functionprotein binding
40005525molecular_functionGTP binding
40005737cellular_componentcytoplasm
40005856cellular_componentcytoskeleton
40005874cellular_componentmicrotubule
40007017biological_processmicrotubule-based process
50000226biological_processmicrotubule cytoskeleton organization
50000278biological_processmitotic cell cycle
50001764biological_processneuron migration
50003924molecular_functionGTPase activity
50005200molecular_functionstructural constituent of cytoskeleton
50005515molecular_functionprotein binding
50005525molecular_functionGTP binding
50005737cellular_componentcytoplasm
50005856cellular_componentcytoskeleton
50005874cellular_componentmicrotubule
50007017biological_processmicrotubule-based process
60000226biological_processmicrotubule cytoskeleton organization
60000278biological_processmitotic cell cycle
60003924molecular_functionGTPase activity
60005200molecular_functionstructural constituent of cytoskeleton
60005525molecular_functionGTP binding
60005737cellular_componentcytoplasm
60005856cellular_componentcytoskeleton
60005874cellular_componentmicrotubule
60007017biological_processmicrotubule-based process
60015630cellular_componentmicrotubule cytoskeleton
60030182biological_processneuron differentiation
70000226biological_processmicrotubule cytoskeleton organization
70000278biological_processmitotic cell cycle
70001764biological_processneuron migration
70003924molecular_functionGTPase activity
70005200molecular_functionstructural constituent of cytoskeleton
70005515molecular_functionprotein binding
70005525molecular_functionGTP binding
70005737cellular_componentcytoplasm
70005856cellular_componentcytoskeleton
70005874cellular_componentmicrotubule
70007017biological_processmicrotubule-based process
80000226biological_processmicrotubule cytoskeleton organization
80000278biological_processmitotic cell cycle
80003924molecular_functionGTPase activity
80005200molecular_functionstructural constituent of cytoskeleton
80005525molecular_functionGTP binding
80005737cellular_componentcytoplasm
80005856cellular_componentcytoskeleton
80005874cellular_componentmicrotubule
80007017biological_processmicrotubule-based process
80015630cellular_componentmicrotubule cytoskeleton
80030182biological_processneuron differentiation
a0000226biological_processmicrotubule cytoskeleton organization
a0000278biological_processmitotic cell cycle
a0003924molecular_functionGTPase activity
a0005200molecular_functionstructural constituent of cytoskeleton
a0005525molecular_functionGTP binding
a0005737cellular_componentcytoplasm
a0005856cellular_componentcytoskeleton
a0005874cellular_componentmicrotubule
a0007017biological_processmicrotubule-based process
a0015630cellular_componentmicrotubule cytoskeleton
a0030182biological_processneuron differentiation
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003924molecular_functionGTPase activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0007017biological_processmicrotubule-based process
A0015630cellular_componentmicrotubule cytoskeleton
A0030182biological_processneuron differentiation
b0000226biological_processmicrotubule cytoskeleton organization
b0000278biological_processmitotic cell cycle
b0001764biological_processneuron migration
b0003924molecular_functionGTPase activity
b0005200molecular_functionstructural constituent of cytoskeleton
b0005515molecular_functionprotein binding
b0005525molecular_functionGTP binding
b0005737cellular_componentcytoplasm
b0005856cellular_componentcytoskeleton
b0005874cellular_componentmicrotubule
b0007017biological_processmicrotubule-based process
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0001764biological_processneuron migration
B0003924molecular_functionGTPase activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0007017biological_processmicrotubule-based process
m0000775cellular_componentchromosome, centromeric region
m0000776cellular_componentkinetochore
m0003777molecular_functionmicrotubule motor activity
m0005524molecular_functionATP binding
m0005634cellular_componentnucleus
m0005856cellular_componentcytoskeleton
m0005874cellular_componentmicrotubule
m0005881cellular_componentcytoplasmic microtubule
m0007018biological_processmicrotubule-based movement
m0007019biological_processmicrotubule depolymerization
m0008017molecular_functionmicrotubule binding
m0035371cellular_componentmicrotubule plus-end
m0051310biological_processmetaphase chromosome alignment
m0051315biological_processattachment of mitotic spindle microtubules to kinetochore
M0000775cellular_componentchromosome, centromeric region
M0000776cellular_componentkinetochore
M0003777molecular_functionmicrotubule motor activity
M0005524molecular_functionATP binding
M0005634cellular_componentnucleus
M0005856cellular_componentcytoskeleton
M0005874cellular_componentmicrotubule
M0005881cellular_componentcytoplasmic microtubule
M0007018biological_processmicrotubule-based movement
M0007019biological_processmicrotubule depolymerization
M0008017molecular_functionmicrotubule binding
M0035371cellular_componentmicrotubule plus-end
M0051310biological_processmetaphase chromosome alignment
M0051315biological_processattachment of mitotic spindle microtubules to kinetochore
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
2GLY142-GLY148
1GLY142-GLY148
site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
2MET1-ILE4
site_idPS00411
Number of Residues12
DetailsKINESIN_MOTOR_1 Kinesin motor domain signature. GKFsLVDLAGNE
ChainResidueDetails
MGLY490-GLU501
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsMotif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues108
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues18
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues18
DetailsMotif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues42
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues62
DetailsRegion: {"description":"Negative regulator of microtubule-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

257179

PDB entries from 2026-07-29

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