9RX4
VPS34-CI bound to NRBF2 and RAB1A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 3-kinase catalytic subunit type 3 | polymer | 887 | 101680.3 | 1 | UniProt (Q8NEB9) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34 |
| 2 | B (B) | Phosphoinositide 3-kinase regulatory subunit 4 | polymer | 1370 | 154659.2 | 1 | UniProt (Q99570) Pfam (PF00069) Pfam (PF22956) Pfam (PF00400) | Homo sapiens (human) | PI3-kinase regulatory subunit 4,PI3-kinase p150 subunit,Phosphoinositide 3-kinase adaptor protein |
| 3 | C, F (C, I) | Beclin-1 | polymer | 450 | 51953.1 | 2 | UniProt (Q14457) Pfam (PF04111) Pfam (PF15285) Pfam (PF17675) | Homo sapiens (human) | Coiled-coil myosin-like BCL2-interacting protein,Protein GT197 |
| 4 | D (D) | Beclin 1-associated autophagy-related key regulator | polymer | 493 | 55461.3 | 1 | UniProt (Q6ZNE5) Pfam (PF10186) | Homo sapiens (human) | Barkor,Autophagy-related protein 14-like protein,Atg14L |
| 5 | E (E) | Ras-related protein Rab-1A | polymer | 207 | 22834.8 | 1 | UniProt (P62820) Pfam (PF00071) | Homo sapiens (human) | YPT1-related protein |
| 6 | G (L) | Nuclear receptor-binding factor 2 | polymer | 308 | 34852.3 | 1 | UniProt (Q96F24) Pfam (PF17169) Pfam (PF08961) | Homo sapiens (human) | NRBF-2,Comodulator of PPAR and RXR |
| 7 | H (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 8 | I, N (B, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 9 | J (B) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 10 | K, L (C, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 11 | M (E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) |
Sequence modifications
B: 2 - 1358 (UniProt: Q99570)
D: 2 - 492 (UniProt: Q6ZNE5)
E: 1 - 204 (UniProt: P62820)
L: 1 - 287 (UniProt: Q96F24)
| PDB | External Database | Details |
|---|---|---|
| Ser 1359 | - | expression tag |
| Arg 1360 | - | expression tag |
| Pro 1361 | - | expression tag |
| Thr 1362 | - | expression tag |
| Thr 1363 | - | expression tag |
| Ala 1364 | - | expression tag |
| Ser 1365 | - | expression tag |
| Glu 1366 | - | expression tag |
| Asn 1367 | - | expression tag |
| Leu 1368 | - | expression tag |
| Tyr 1369 | - | expression tag |
| Phe 1370 | - | expression tag |
| Gln 1371 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Thr 1 | - | expression tag |
| Ser 256 | Asn 256 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 26 | Cys 26 | engineered mutation |
| Leu 70 | Gln 70 | engineered mutation |
| Ser 126 | Cys 126 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Ala -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 473394.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1374.2 | |
| All* | Total formula weight | 474768.3 |
