9PYF

uPA Inhibitory Fab AB2 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, I)	AB2 Fab Light Chain	polymer	216	23666.4	2		Homo sapiens
2	B (F)	Urokinase-type plasminogen activator	polymer	284	32114.6	1	UniProt (P00749) Pfam (PF00089)	Homo sapiens (human)	U-plasminogen activator,uPA
3	D, E (D, H)	AB2 Fab Heavy Chain	polymer	213	22459.2	2		Homo sapiens
4	F, G, H (A, F, D)	water	water		18.0	44	Chemie (HOH)

Sequence modifications

F: -7 - 244 (UniProt: P00749)

PDB	External Database	Details
Met -21	-	initiating methionine
Arg -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Ala -9	-	expression tag
Cys -8	-	expression tag
Ala 122	Cys 299	engineered mutation
Gln 145	Asn 322	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	124365.8
All*	Total formula weight	124365.8

*Water molecules are not included.