9P0X
Nanodisc-embedded human TF/FVIIa/XK1 in complex with 10H10 Fab (nanodisc-subtracted)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (V) | Factor VII light chain | polymer | 142 | 16359.8 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 2 | B (X) | Factor X light chain | polymer | 131 | 15309.4 | 1 | UniProt (P00742) Pfam (PF00008) Pfam (PF14670) Pfam (PF00594) | Homo sapiens (human) | |
| 3 | C (S) | Coagulation factor VII Heavy Chain | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 4 | D (T) | Tissue factor,Maltose/maltodextrin-binding periplasmic protein | polymer | 611 | 67828.5 | 1 | UniProt (P13726) UniProt (P0AEY0) Pfam (PF01108) Pfam (PF09294) Pfam (PF01547) UniProt (by SIFTS) (P0AEX9) | Homo sapiens (human) | TF,Coagulation factor III,Thromboplastin,MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP |
| 5 | E (K) | Tissue factor pathway inhibitor | polymer | 68 | 7979.2 | 1 | UniProt (P10646) Pfam (PF00014) | Homo sapiens (human) | TFPI,Extrinsic pathway inhibitor,EPI,Lipoprotein-associated coagulation inhibitor,LACI |
| 6 | F (H) | Human 10H10 antibody Fab heavy chain | polymer | 221 | 23569.3 | 1 | Mus musculus (mouse) | ||
| 7 | G (L) | Human 10H10 antibody Fab light chain | polymer | 220 | 24196.7 | 1 | Mus musculus (mouse) | ||
| 8 | H, K, N, X (V, X) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 9 | I, J, L, M, Q... (V, X, S) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 10 | O (V) | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 11 | P (V) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) |
Sequence modifications
T: 6 - 244 (UniProt: P13726)
T: 251 - 616 (UniProt: P0AEY0)
| PDB | External Database | Details |
|---|---|---|
| Gly 245 | - | linker |
| Ser 246 | - | linker |
| Gly 247 | - | linker |
| Ser 248 | - | linker |
| Gly 249 | - | linker |
| Met 250 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 183346.1 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 922.5 | |
| All* | Total formula weight | 184268.6 |
