9OP3
Structure of Human ADAR2-R2D complexed with dsRNA containing 8-azaN and 2'-Deoxy-2'-fluorouridine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Double-stranded RNA-specific editase 1 | polymer | 488 | 53989.7 | 2 | UniProt (P78563) Pfam (PF00035) Pfam (PF02137) | Homo sapiens (human) | RNA-editing deaminase 1,RNA-editing enzyme 1,dsRNA adenosine deaminase |
| 2 | C (C) | RNA 32mer Top Strand | polymer | 32 | 10316.1 | 1 | Homo sapiens | ||
| 3 | D (D) | RNA 32mer 2F Bottom Strand | polymer | 32 | 10215.1 | 1 | Homo sapiens | ||
| 4 | E, K (A, B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 5 | F, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | G, H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 7 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B: 215 - 701 (UniProt: P78563)
| PDB | External Database | Details |
|---|---|---|
| Gly 214 | - | expression tag |
| Gln 488 | Glu 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128510.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1660.1 | |
| All* | Total formula weight | 130170.8 |
