9OC7

Crystal structure of FcRn in complex with Human Astrovirus 2 spike

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (X, D)	Spike protein VP25	polymer	249	28720.4	2	UniProt (Q82446)	Human astrovirus 2
2	B, E (Y, E)	IgG receptor FcRn large subunit p51	polymer	274	30408.1	2	UniProt (P55899) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor
3	C, F (Z, F)	Beta-2-microglobulin	polymer	99	11748.2	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)

Sequence modifications

X, D: 428 - 647 (UniProt: Q82446)

PDB	External Database	Details
Met 427	-	initiating methionine
Gly 648	-	expression tag
Ser 649	-	expression tag
Gly 650	-	expression tag
Leu 651	-	expression tag
Asn 652	-	expression tag
Asp 653	-	expression tag
Ile 654	-	expression tag
Phe 655	-	expression tag
Glu 656	-	expression tag
Ala 657	-	expression tag
Gln 658	-	expression tag
Lys 659	-	expression tag
Ile 660	-	expression tag
Glu 661	-	expression tag
Trp 662	-	expression tag
His 663	-	expression tag
Glu 664	-	expression tag
Gly 665	-	expression tag
His 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
His 672	-	expression tag
His 673	-	expression tag
His 674	-	expression tag
His 675	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	141753.3
All*	Total formula weight	141753.3

*Water molecules are not included.