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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9OC7

Crystal structure of FcRn in complex with Human Astrovirus 2 spike

Functional Information from GO Data
ChainGOidnamespacecontents
F0000139cellular_componentGolgi membrane
F0002376biological_processimmune system process
F0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
F0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
F0002502biological_processpeptide antigen assembly with MHC class I protein complex
F0002503biological_processpeptide antigen assembly with MHC class II protein complex
F0002715biological_processregulation of natural killer cell mediated immunity
F0002726biological_processpositive regulation of T cell cytokine production
F0005198molecular_functionstructural molecule activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005765cellular_componentlysosomal membrane
F0005783cellular_componentendoplasmic reticulum
F0005788cellular_componentendoplasmic reticulum lumen
F0005794cellular_componentGolgi apparatus
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006879biological_processintracellular iron ion homeostasis
F0007608biological_processsensory perception of smell
F0007611biological_processlearning or memory
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0010038biological_processresponse to metal ion
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
F0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
F0023026molecular_functionMHC class II protein complex binding
F0030670cellular_componentphagocytic vesicle membrane
F0031901cellular_componentearly endosome membrane
F0031902cellular_componentlate endosome membrane
F0031905cellular_componentearly endosome lumen
F0033572biological_processtransferrin transport
F0034756biological_processregulation of iron ion transport
F0034757biological_processnegative regulation of iron ion transport
F0035580cellular_componentspecific granule lumen
F0042605molecular_functionpeptide antigen binding
F0042612cellular_componentMHC class I protein complex
F0042613cellular_componentMHC class II protein complex
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042824cellular_componentMHC class I peptide loading complex
F0048260biological_processpositive regulation of receptor-mediated endocytosis
F0048261biological_processnegative regulation of receptor-mediated endocytosis
F0050680biological_processnegative regulation of epithelial cell proliferation
F0050768biological_processnegative regulation of neurogenesis
F0050778biological_processpositive regulation of immune response
F0050870biological_processpositive regulation of T cell activation
F0051289biological_processprotein homotetramerization
F0055038cellular_componentrecycling endosome membrane
F0070062cellular_componentextracellular exosome
F0071281biological_processcellular response to iron ion
F0071316biological_processcellular response to nicotine
F1904724cellular_componenttertiary granule lumen
F1990000biological_processamyloid fibril formation
F1990712cellular_componentHFE-transferrin receptor complex
F2000774biological_processpositive regulation of cellular senescence
F2000978biological_processnegative regulation of forebrain neuron differentiation
Z0000139cellular_componentGolgi membrane
Z0002376biological_processimmune system process
Z0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
Z0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
Z0002502biological_processpeptide antigen assembly with MHC class I protein complex
Z0002503biological_processpeptide antigen assembly with MHC class II protein complex
Z0002715biological_processregulation of natural killer cell mediated immunity
Z0002726biological_processpositive regulation of T cell cytokine production
Z0005198molecular_functionstructural molecule activity
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005615cellular_componentextracellular space
Z0005765cellular_componentlysosomal membrane
Z0005783cellular_componentendoplasmic reticulum
Z0005788cellular_componentendoplasmic reticulum lumen
Z0005794cellular_componentGolgi apparatus
Z0005886cellular_componentplasma membrane
Z0005925cellular_componentfocal adhesion
Z0006879biological_processintracellular iron ion homeostasis
Z0007608biological_processsensory perception of smell
Z0007611biological_processlearning or memory
Z0009897cellular_componentexternal side of plasma membrane
Z0009986cellular_componentcell surface
Z0010038biological_processresponse to metal ion
Z0012507cellular_componentER to Golgi transport vesicle membrane
Z0016020cellular_componentmembrane
Z0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
Z0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
Z0023026molecular_functionMHC class II protein complex binding
Z0030670cellular_componentphagocytic vesicle membrane
Z0031901cellular_componentearly endosome membrane
Z0031902cellular_componentlate endosome membrane
Z0031905cellular_componentearly endosome lumen
Z0033572biological_processtransferrin transport
Z0034756biological_processregulation of iron ion transport
Z0034757biological_processnegative regulation of iron ion transport
Z0035580cellular_componentspecific granule lumen
Z0042605molecular_functionpeptide antigen binding
Z0042612cellular_componentMHC class I protein complex
Z0042613cellular_componentMHC class II protein complex
Z0042802molecular_functionidentical protein binding
Z0042803molecular_functionprotein homodimerization activity
Z0042824cellular_componentMHC class I peptide loading complex
Z0048260biological_processpositive regulation of receptor-mediated endocytosis
Z0048261biological_processnegative regulation of receptor-mediated endocytosis
Z0050680biological_processnegative regulation of epithelial cell proliferation
Z0050768biological_processnegative regulation of neurogenesis
Z0050778biological_processpositive regulation of immune response
Z0050870biological_processpositive regulation of T cell activation
Z0051289biological_processprotein homotetramerization
Z0055038cellular_componentrecycling endosome membrane
Z0070062cellular_componentextracellular exosome
Z0071281biological_processcellular response to iron ion
Z0071316biological_processcellular response to nicotine
Z1904724cellular_componenttertiary granule lumen
Z1990000biological_processamyloid fibril formation
Z1990712cellular_componentHFE-transferrin receptor complex
Z2000774biological_processpositive regulation of cellular senescence
Z2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH
ChainResidueDetails
YTYR250-HIS256
ZTYR78-HIS84
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues174
DetailsDomain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues178
DetailsRegion: {"description":"Alpha-2","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues178
DetailsRegion: {"description":"Alpha-3","evidences":[{"source":"PubMed","id":"10933786","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsRegion: {"description":"Connecting peptide"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues176
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248942

PDB entries from 2026-02-11

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