9L1S
Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor tyrosine-protein kinase erbB-2 | polymer | 636 | 70295.8 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | B (B) | Pertuzumab Fab light chain | polymer | 214 | 23548.2 | 1 | Homo sapiens | ||
| 3 | C (C) | Pertuzumab Fab heavy chain | polymer | 227 | 24201.1 | 1 | Homo sapiens |
Sequence modifications
A: 23 - 652 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Phe 310 | Ser 310 | engineered mutation |
| Val 435 | Ile 435 | conflict |
| His 653 | - | expression tag |
| His 654 | - | expression tag |
| His 655 | - | expression tag |
| His 656 | - | expression tag |
| His 657 | - | expression tag |
| His 658 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118045.0 | |
| All* | Total formula weight | 118045.0 |
