9JCZ
Cryo-EM structure of human TauT in presence of taurine, determined in an inward-facing occluded conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium- and chloride-dependent taurine transporter | polymer | 606 | 68496.0 | 1 | UniProt (P31641) Pfam (PF00209) | Homo sapiens (human) | Solute carrier family 6 member 6 |
| 2 | B, C, K (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 3 | D, E (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 5 | G, H, I, J (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 6 | L (A) | 2-AMINOETHANESULFONIC ACID | non-polymer | 125.1 | 1 | Chemie (TAU) PubChem (1123) | |||
| 7 | M (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 582 (UniProt: P31641)
| PDB | External Database | Details |
|---|---|---|
| Ser 583 | - | expression tag |
| Arg 584 | - | expression tag |
| Leu 585 | - | expression tag |
| Glu 586 | - | expression tag |
| Glu 587 | - | expression tag |
| Glu 588 | - | expression tag |
| Leu 589 | - | expression tag |
| Arg 590 | - | expression tag |
| Arg 591 | - | expression tag |
| Arg 592 | - | expression tag |
| Thr 593 | - | expression tag |
| Glu 594 | - | expression tag |
| Pro 595 | - | expression tag |
| Gly 596 | - | expression tag |
| Leu 597 | - | expression tag |
| Arg 598 | - | expression tag |
| Ser 599 | - | expression tag |
| Arg 600 | - | expression tag |
| Leu 601 | - | expression tag |
| Glu 602 | - | expression tag |
| Val 603 | - | expression tag |
| Leu 604 | - | expression tag |
| Phe 605 | - | expression tag |
| Gln 606 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 68496.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2817.1 | |
| All* | Total formula weight | 71313.1 |
