9JCZ
Cryo-EM structure of human TauT in presence of taurine, determined in an inward-facing occluded conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005283 | molecular_function | amino acid:sodium symporter activity |
| A | 0005332 | molecular_function | gamma-aminobutyric acid:sodium:chloride symporter activity |
| A | 0005368 | molecular_function | taurine transmembrane transporter activity |
| A | 0005369 | molecular_function | taurine:sodium symporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015185 | molecular_function | gamma-aminobutyric acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015734 | biological_process | taurine transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022858 | molecular_function | alanine transmembrane transporter activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0031528 | cellular_component | microvillus membrane |
| A | 0032328 | biological_process | alanine transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042995 | cellular_component | cell projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0045597 | biological_process | positive regulation of cell differentiation |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0051939 | biological_process | gamma-aminobutyric acid import |
| A | 0089718 | biological_process | amino acid import across plasma membrane |
| A | 0098739 | biological_process | import across plasma membrane |
| A | 0098982 | cellular_component | GABA-ergic synapse |
| A | 0150104 | biological_process | transport across blood-brain barrier |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF |
| Chain | Residue | Details |
| A | TRP65-PHE79 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfqSFQkeLPWahCnhswNT |
| Chain | Residue | Details |
| A | TYR148-THR168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ASP49 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE50-LEU70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA78-LEU97 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY122-LEU142 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA143-LYS217 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP218-TRP236 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL245-VAL262 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE298-TYR315 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET327-LEU348 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET381-LEU400 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE430-THR448 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY465-GLY485 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR506-VAL525 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU545-ILE563 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q00589 |
| Chain | Residue | Details |
| A | SER322 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN163 | |
| A | ASN179 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN190 |
