9IZN

Crystal structure of HKU1A RBD bound to TMPRSS2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Transmembrane protease serine 2	polymer	392	43473.9	1	UniProt (O15393) Pfam (PF15494) Pfam (PF00089)	Homo sapiens (human)	Serine protease 10
2	B (A)	Spike protein S1	polymer	379	42530.2	1	UniProt (Q5MQD0) Pfam (PF09408) Pfam (PF19209)	Human coronavirus HKU1 (isolate N1)
3	C, D (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	E, F (B, A)	water	water		18.0	281	Chemie (HOH)

Sequence modifications

B: 109 - 492 (UniProt: O15393)

PDB	External Database	Details
Gln 255	Arg 255	engineered mutation
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag

A: 307 - 677 (UniProt: Q5MQD0)

PDB	External Database	Details
His 678	-	expression tag
His 679	-	expression tag
His 680	-	expression tag
His 681	-	expression tag
His 682	-	expression tag
His 683	-	expression tag
His 684	-	expression tag
His 685	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86004.2
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	86446.6

*Water molecules are not included.